University of California San Francisco

Basu Lab Research Test

Leveraging Artificial Intelligence and Machine Learning Methodology to Advance Cancer Research

Modern cancer therapies have dramatically improved outcomes, but they also introduce complex and sometimes long-lasting side effects that can impact quality of life long after treatment ends. Our research uses artificial intelligence (AI) and machine learning (ML) to better understand why patients experience toxicities differently—and how symptoms evolve over time—so that supportive care and treatment planning can become more proactive, personalized, and effective.

We develop computational models that integrate clinical factors, patient-reported outcomes (PROs), laboratory biomarkers, and germline genetic information to predict which patients are most likely to experience significant toxicity or declines in quality of life. By combining longitudinal symptom tracking with biologic and genetic signals, our goal is to identify early warning patterns and build decision-support tools that help clinicians optimize therapy while minimizing long-term harm.

Areas of Research

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AI and ML enable us to learn from complex, high-dimensional cancer data that traditional methods cannot easily capture—especially when outcomes evolve over time and are influenced by multiple interacting factors. Our models integrate diverse data sources (clinical characteristics, PROs, genomics ...  Read More
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Treatment toxicities and resistance often share overlapping biology, including inflammation, immune activation, and tissue-specific vulnerability. Our lab investigates biomarker signals that reflect both toxicity risk and therapeutic response, helping to clarify which biological pathways contribute to favorable anti-tumor immunity versus ...  Read More
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Genetic variation across patients can shape immune reactivity, inflammation, drug metabolism, and recovery patterns. Our work investigates how germline genetics contribute to the risk of treatment-related adverse events, with particular focus on immune-related toxicities associated with immune checkpoint inhibitors (ICIs) ...  Read More
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Symptoms are often the earliest and most sensitive indicators of treatment burden. Our research characterizes the full symptom landscape experienced by early-stage breast cancer patients. We use validated PRO instruments to capture symptom severity and functional impact at high resolution ...  Read More